Nasosorption™ FX·i

Nasosorption™ FX·i uses a synthetic absorptive matrix (SAM™) swab to gently absorb mucosal lining fluid from the mucosa in the lower nasal turbinate.

Our design is engineered for targeted sampling with minimal patient discomfort.

Our unique products are the result of years of clinical feedback, delivering a product which is aimed to reduce patient discomfort and designed to be simple to use.

The sampling technique does not require a local anaesthetic, and is applicable to many infectious and inflammatory disorders. Successful nasal pilot studies have been performed in adults with hay fever, as well as nasal sampling in babies and in young children.

SAM™ material is developed for wicking and absorption to achieve quick, comfortable nasal sampling, with minimal binding of proteins and mediators for good sample recovery. Nasosorption™ FX·i is designed to collect a mucosal lining fluid sample from the lower nasal turbinate.

SAM™ is a soft, absorbent, fibrous material that can be inserted into a nostril. Nasosorption™ FX·i is comfortable to use and can obtain mucosal lining fluid (MLF) at frequent intervals over extended periods, making it suitable for time-dependent studies.

Nasosorption FX·i has a fixed length applicator handle which is designed to screw into the supplied cryogenic tube for storage down to -80℃. Mucosal lining fluid samples can be collected and rapidly frozen for subsequent analysis.

Cryogenic Tube

The Nasosorption FX·i nasal sampling device consists of a synthetic absorptive matrix (SAM™) swab developed for effective wicking and absorption.

SAM swab

Nasosorption FX·i is currently available in three sizes which are designed for use in neonates, infants and adults: 3.0 mm, 4.5 mm, 7.0 mm

Product range

Nasosorption FX·i is CE marked non-invasive nasal sampling device.


The Mucosal Diagnostics product range is manufactured in a medical device production facility with Cleanrooms validated to meet the requirements of ISO 14644


Our products are subject to gamma irradiation process using Cobalt 60 radiation to kill micro-organisms.

Gamma Irradiated
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Nasosorption - Eosinophil

Please note that the eosinophil film does not have a sound commentary...
...but shows the migration of this beautiful cell from the blood into the airways, where
it is a major feature in asthma patients. To begin at the beginning, having been
produced in the bone marrow, we see the eosinophil in a blood vessel. The eosinophil
has its characteristic bright red granules, staining with the dye eosin (named after the
Goddess of the Dawn), and containing some of the most basic proteins found in man
(including MBP and ECP). There is a characteristic bilobed blue nucleus, that has a
small bridge between the 2 lobes. We first see the eosinophil in a blood vessel,
moving along with a red blood cell. The eosinophil starts to roll down the wall of the
capillary, before cell adhesion, and then by the process of diapedesis it migrates
between the capillary endothelial cells into the interstitium of the airway wall.
We then see many eosinophils accumulating in the airway wall and this eosinophil-
related inflammation then causing asthma. However, blood eosinophil counts are too
variable, and sputum eosinophils are difficult to measure. That is why nasosorption
and absorption of mucosal lining fluid from other parts of the respiratory tract is
important: to precisely measure the molecules (such as interleukin (IL)-5) that cause
the eosinophil inflammation.

Targeted Therapy

Taking the right sample enables molecular events to be measured in mucous membranes. Since patients with various inflammatory diseases such as hay fever, asthma, and inflammatory bowel disease may have many differing individual patterns of inflammation, this enables the right highly specific treatment to be given to the right patient.

Many diseases of the respiratory tract and gastrointestinal tract cause inflammation, and existing methods of sampling have significant drawbacks. Development of the Mucosal Diagnostics product range has been driven by an urgent need for new methods of taking samples.

Patient Comfort

Maintaining patient comfort during sampling is one of our key objectives and we strive to overcome patient discomfort experienced during other common sampling procedures.


The Mucosal Diagnostics™ range of products are manufactured by Hunt Developments (UK) Limited, who have over 32 years experience in the production of medical devices and healthcare products.


The Imperial Clinical Respiratory Research Unit (ICRRU) at St Mary’s Hospital works closely with clinicians and Imperial College London to develop new methods of sampling from the airways, identification of biomarkers, and testing of new therapies and vaccines for respiratory diseases

State Of The Art Production

Our state of the art production facilities meet the requirements of ISO 14644 and are electronically monitored 24 hours a day.

Mucosal Sampling

Mucous membranes comprise the moist epithelial surfaces found in the nose and airways, the mouth and gastrointestinal tract, the urogenital tract, the eyes and ears. Measurement of markers and mediators in the mucosal lining fluid has widespread applications.

Mucosal lining fluid (MLF) reflects the health of the underlying cells in the mucous membrane. In the respiratory system, sampling and analysis of the MLF may be relevant to infections (colds, influenza, bacterial pneumonia, TB), to allergy and asthma, to cigarette-induced lung disease (COPD), to malignancies and to cystic fibrosis.

Using MLF to identify molecular signatures of respiratory disease can achieve fundamental insights into the mechanism of diseases. This refines the diagnosis, stratification and monitoring of a variety of airway diseases in patients of all ages. In particular, biomarkers can be discovered to help assess the effects of therapies and identify potential targets for novel treatments.

About Mucosal Diagnostics

The Mucosal Diagnostics product range currently includes nasal and bronchial sampling devices, developed for the collection of mucosal lining fluid, to aid in the diagnosis of infectious and inflammatory disorders.

We aim to develop products which minimise patient discomfort and are easy to use by clinicians and healthcare professionals.

Through a collaboration between Hunt Developments and Imperial College, our team of clinicians and engineers are dedicated to improving the sampling process and the patient experience.

Mucosal Diagnostics
Unit 17, Holmbush Industrial Estate,
Midhurst, West Sussex, GU29 9HX, England
+44(0)1730 858792

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